Curcumin-Piperine Supplementation in STEMI - SPICE STEMI Trial
Curcumin-Piperine Supplementation in STEMI - SPICE STEMI Trial
NCT ID: NCT07149961 Phase: NA Status: COMPLETED Enrollment: 50 Completion: 2025-05-20
Conditions
ST Elevation Myocardial Infarction (STEMI), Malondialdehyde, Hs-CRP, Curcumin, Curcuma Xanthorrhiza, High-sensitivity C-reactive Protein
Interventions
Curcumin plus Piperine, Placebo capsules
Summary
This study aims to evaluate whether supplementation with a combination of curcumin and piperine can help reduce inflammation and oxidative stress in patients who have experienced a heart attack called ST-Elevation Myocardial Infarction (STEMI) and are undergoing a procedure known as primary percutaneous coronary intervention (PPCI).
Curcumin, a natural compound from turmeric, is known for its antioxidant and anti-inflammatory effects, but it is not easily absorbed by the body. Piperine, a compound from black pepper, can improve curcumin absorption. By combining the two, we hope to maximize their potential benefits.
The study will measure markers of inflammation (high-sensitivity C-reactive protein, hsCRP) and oxidative stress (malondialdehyde, MDA) at three time points: before treatment, shortly after the PPCI procedure, and after 28 days of supplementation.
The main question is whether curcumin-piperine supplementation can provide additional protection against inflammation and oxidative stress compared to a placebo, potentially supporting recovery and reducing the risk of future heart problems.
Primary Outcome
Change from Baseline in Serum High-Sensitivity C-Reactive Protein (hsCRP) at Day 28