EFFECTS OF PYRROLOQUINOLINE QUINONE (PQQ) SUPPLEMENTATION ON NON-ENDURANCE TRAINED ATHLETES
EFFECTS OF PYRROLOQUINOLINE QUINONE (PQQ) SUPPLEMENTATION ON NON-ENDURANCE TRAINED ATHLETES
NCT ID: NCT07148726 Phase: NA Status: COMPLETED Enrollment: 24 Completion: 2025-08-15
Conditions
Mitochondrial Biogenesis, Inflammation
Interventions
Pyrrole Quinoline Quinone (PQQ), Placebo
Summary
The aim of this study was to investigate the effects of six weeks of PQQ supplementation in non-endurance-trained individuals on:
- physiological and metabolic response during a FATmax-VO₂peak exercise test
- resting energy expenditure, body composition and blood biomarkers (fasting glucose, lactate dehydrogenase (LDH), creatine phosphokinase (CPK) and C-reactive protein (CRP) levels)
- blood and urine omics markers of oxidative metabolism 24 basketball players will be randomized to consume a supplement containing 20 mg/day of PQQ or placebo (PLA) during a six-week intervention. Subjects will be encouraged to maintain their usual diet and training schedule. Body composition will be assessed by dual-energy-x-ray-absorptiometry and bioimpedance analysis. Aerobic exercise performance will be evaluated through a graded exercise protocol (six 5-minutes steps followed by n 2-minutes steps until exhaustion; the initial workload was 60 watts and increased by 35 watts at the end of each step) performed on a cycle ergometer. Capillary blood lactate samples were collected at the end of each step. Blood and urine samples were also collected, and metabolomics analysis will be performed.
Primary Outcome
Fat oxidation during FATmax-VO₂peak exercise test using gas analyzer.