Low-FODMAP Diet and Probiotics: Effects on Gut, Behavior, and Microbiota in Children With Autism Spectrum Disorder
Low-FODMAP Diet and Probiotics: Effects on Gut, Behavior, and Microbiota in Children With Autism Spectrum Disorder
NCT ID: NCT07086157 Phase: NA Status: COMPLETED Enrollment: 16 Completion: 2024-03-01
Conditions
Autism Spectrum Disorder, Functional Gastrointestinal Disorders
Interventions
Probiotic, Low-FODMAP Diet
Summary
The goal of this clinical trial was to evaluate whether a low-FODMAP diet and probiotic supplements could reduce gastrointestinal (GI) symptoms and behavior problems in children with autism spectrum disorder (ASD) who also experienced GI issues. The main questions it aimed to answer were:
Did a low-FODMAP diet and/or probiotics improve GI symptoms such as constipation, diarrhea, and abdominal pain?
Did these interventions help reduce behavior problems such as irritability, lethargy, stereotypy, hyperactivity, and speech disorder ?
Researchers compared two groups:
- Children who received a daily probiotic supplement containing 4 strains for 4 weeks
- Children who received both the probiotic supplement and followed a low-FODMAP diet
This comparison aimed to determine whether the combination of diet and probiotics had greater benefits than probiotics alone.
Participants:
Took the assigned intervention(s) for 4 weeks
Provided stool samples for gut microbiota analysis
Completed assessments of GI symptoms and behavior using validated questionnaires
Primary Outcome
Change in Aberrant Behavior Checklist (ABC) Irritability Subscale Score