The Potential Effect of the Local Administration of Vitamins C and E on Orthodontic Treatment: A Randomized Clinical Trial
The Potential Effect of the Local Administration of Vitamins C and E on Orthodontic Treatment: A Randomized Clinical Trial
NCT ID: NCT06847880 Phase: PHASE1 Status: COMPLETED Enrollment: 51 Completion: 2026-02-28
Conditions
Pain Perception, Root Resorption, Rate of Orthodontic Tooth Movement, Biomarkers
Interventions
1: Vitamin C Supplementation, Vitamin E Supplementation, Saline Solution (Control)
Summary
Brief Summary of the Study
This study investigates the effects of locally administered vitamins C and E on orthodontic tooth movement during the initial stage of treatment. Orthodontic tooth movement relies on bone remodeling, which can be influenced by antioxidants like vitamins C and E. Vitamin C promotes collagen formation and osteoblast activity, while vitamin E has anti-inflammatory and antioxidant properties that may impact bone metabolism.
The study is a randomized clinical trial conducted in multiple clinics, where patients will be divided into three groups:
- Control group - receives a saline injection.
- Vitamin C group - receives a local injection of vitamin C.
- Vitamin E group - receives a local injection of vitamin E.
Injections will be administered every two weeks for vitamin C and every month for vitamin E, for six months, while patients undergo orthodontic treatment with fixed appliances. Researchers will evaluate the rate of tooth movement, root resorption, pain perception, and patient experience. Additionally, biomarkers related to bone remodeling will be measured in gingival crevicular fluid at different time points.
The study aims to determine whether local administration of vitamins C or E enhances orthodontic tooth movement and elevate their effects on the orthodontic potential side effects like root resorption and pain. The findings may provide valuable insights into optimizing orthodontic treatment with the help of antioxidants.
Primary Outcome
Difference in the amount of crowding relief of the mandibular incisors before treatment and at 4, 8, 12, 16, 20, and 24 weeks after the start of treatment among the two vitamins and control groups