Acute and Long-term Health Effects of Various Carbohydrates on Blood Glucose Management in Humans
Acute and Long-term Health Effects of Various Carbohydrates on Blood Glucose Management in Humans
NCT ID: NCT06554002 Phase: NA Status: COMPLETED Enrollment: 98 Completion: 2023-08-14
Conditions
Nutrition, Healthy
Interventions
Control, Treatment
Summary
Dietary fibre, especially soluble fibre, has several health benefits such as lowering the risks for cardiovascular disease, stroke, diabetes, obesity, and gastrointestinal diseases. Resistant dextrin is a non-viscous soluble fibre, can be introduced quite easily in foods or as drinks, and it is well tolerated. This study aims to investigate if daily supplementation of habitual diets with resistant dextrin over 8 weeks affect glycaemic control via insulin sensitivity, intestinal fermentation, energy expenditure and fat oxidation in adults with increased risk for type 2 diabetes. The primary outcome is the effect on glycaemic control (fasting glucose, insulin, insulin sensitivity and 24 hour glycaemic response from CGMS). The secondary outcomes are the effects on fasting lipids, energy expenditure and fuel utilization in a whole room calorimeter and appetite regulation.
Primary Outcome
Glucose will be measured from fasting blood samples that will be collected at baseline (0 week), follow up visit (at 4 weeks) and at the end of the intervention (at 8 weeks).