Effect of Oral Combined Berberine and Curcumin Pharmacological Therapy on IBS
Effect of Oral Combined Berberine and Curcumin Pharmacological Therapy on IBS
NCT ID: NCT06187298 Phase: Status: COMPLETED Enrollment: 146 Completion: 2023-12-15
Conditions
Irritable Bowel Syndrome
Interventions
A combined supplement of Berberine and Curcumin (Enterophytol® PLUS) alongside standard of care
Summary
Irritable bowel syndrome (IBS) is a prevalent, chronic functional gastrointestinal (GI) disorder, characterized by recurrent abdominal discomfort (pain) associated with altered bowel movements. IBS has a considerable negative impact on people's quality of life (QoL). There is currently no specific treatment available for IBS; most of the therapeutic management is symptomatic. Reported evidence suggest that BBR and CUR can alleviate symptoms of IBS through their multiple pharmacological effects including preventing stress-induced intestinal inflammation and visceral hypersensitivity, reducing bowel motility, and regulating intestinal permeability, gut microme and gut-brain axis.
Primary Outcome
Change in the overall IBS Severity Index