Oral Bioavailability of Two Melatonin Supplements
Oral Bioavailability of Two Melatonin Supplements
NCT ID: NCT05835258 Phase: NA Status: COMPLETED Enrollment: 12 Completion: 2023-07-14
Conditions
Bioavailability
Interventions
Melatonin with phenyl capsaicin, Melatonin without phenyl capsaicin
Summary
Results from several clinical studies show that orally administered melatonin has low bioavailability and a very short half-life. Phenyl capsaicin, a synthetic analogue of capsaicin, might increase its bioavailability by inhibiting the enzymes involved in its hepatic metabolism.
Thus, the hypothesis of the present study is that the administration of melatonin supplement with phenyl capsaicin presents greater bioavailability than a melatonin supplement that does not contain phenyl capsaicin.
Primary Outcome
Bioavailability of melatonin calculated by the Area Under The Curve (AUC 0-6) of plasma melatonin levels