Effects of Manual Therapy Combined With Therapeutic Exercise on Brain Biomarkers in Neck Pain
Effects of Manual Therapy Combined With Therapeutic Exercise on Brain Biomarkers in Neck Pain
NCT ID: NCT05568394 Phase: NA Status: COMPLETED Enrollment: 52 Completion: 2024-02-05
Conditions
Neck Pain
Interventions
Manual therapy combinded with therapeutic exercise, Routine physical therapy
Summary
Structural brain alterations in pain-related areas have been demonstrated in patients with nonspecific neck pain. While manual therapy combined with therapeutic exercise is an effective management for neck pain, its underlying mechanisms are poorly understood. The primary objective of this trial is to investigate the effects of manual therapy combined with therapeutic exercise on brain imaging biomarkers in patients with chronic nonspecific neck pain. The secondary objectives are to assess neurochemical biomarkers, clinical features of neck pain, cervical range of motion and cervical muscle strength.
Primary Outcome
Cortical gray matter: volume and thickness