Effect of L-Citrulline Supplementation on NAFLD in Adolescents With Obesity
Effect of L-Citrulline Supplementation on NAFLD in Adolescents With Obesity
NCT ID: NCT04871360 Phase: NA Status: COMPLETED Enrollment: 42 Completion: 2022-01-15
Conditions
Non-Alcoholic Fatty Liver Disease, Obesity
Interventions
L-Citrulline supplement, Carboxymethyl cellulose supplement
Summary
One of the comorbidities of obesity is nonalcoholic fatty liver disease (NAFLD). L-citrulline is a non-protein amino acid that has shown positive effects on the degree of fat retention and metabolic profile in NAFLD. The objective is to assess the effect of oral L-citrulline supplementation on liver function and nonalcoholic fatty liver in adolescents with obesity. A clinical study will be carried out in 40 adolescents (15-19 years) with obesity, they will be divided into a control group that will receive a placebo and an experimental group that will receive 6 g of l-citrulline per day for eight weeks.
Primary Outcome
Degree of hepatic steatosis