Effect of Vitamin D3-fortified Fruit Juice on Iron Status in Women
Effect of Vitamin D3-fortified Fruit Juice on Iron Status in Women
NCT ID: NCT04618289 Phase: NA Status: COMPLETED Enrollment: 45 Completion: 2023-12-01
Conditions
Iron-deficiency
Interventions
Vitamin D3-fortified fruit juice supplement
Summary
The present study is designed to utilise vitamin D3 supplements that may potentially act as an iron absorption enhancer to improve iron status in the Malaysian child-bearing aged women with low iron stores. In addition to investigating the efficacy, this study is also designed to assess the effect of a dose of vitamin D3 (4000 IU) on iron metabolism. The study will include the measurement of plasma hepcidin and 25(OH)D concentrations to investigate a possible mechanism that links vitamin D and iron deficiency, as postulated from the existing literature. For that reason, the aim of the study was to investigate the effect of an 8-week vitamin D3 supplementation on iron status indicators, including hepcidin concentration in childbearing aged Malaysian women with marginal iron stores. It is hypothesised that there will be a significant improvement in haematological indicators following 8-week daily vitamin D3 supplementation in the vitamin D group compared to placebo group. It is also hypothesised that plasma hepcidin concentration will be reduced following 8-week daily vitamin D3 supplementation, which results in increased iron stores.
Primary Outcome
Change of plasma ferritin concentration from baseline (week 0) to post intervention (week 8)