Effect of Combined IV Bolus Amino Acid Supplementation and Mobilisation on Skeletal Muscle During the First 10 Days in the ICU: A RCT
Effect of Combined IV Bolus Amino Acid Supplementation and Mobilisation on Skeletal Muscle During the First 10 Days in the ICU: A RCT
NCT ID: NCT04099108 Phase: NA Status: COMPLETED Enrollment: 50 Completion: 2022-12-31
Conditions
Critical Illness
Interventions
Combined cycle ergometry and bolus amino acid supplementation
Summary
A single-centre, two-arm, parallel randomised controlled trial (RCT) to compare the combined effect of early intravenous bolus amino acid supplementation and mobilisation versus standard of care on changes in muscle mass over the first week in ICU. Half of study participants will receive the study intervention (an intravenous bolus amino acid supplement combined with in-bed cycling), while the other half will receive standard of care only.
Primary Outcome
Change in vastus lateralis myofiber cross-sectional area (biopsy) from pre- to post-intervention.