Licorice Botanical Dietary Supplements - Metabolism and Safety in Women
Licorice Botanical Dietary Supplements - Metabolism and Safety in Women
NCT ID: NCT03948243 Phase: PHASE1 Status: COMPLETED Enrollment: 19 Completion: 2022-04-22
Conditions
Food-drug Interaction
Interventions
Licorice, Alprazolam 2 MG, Caffeine 100 MG, Tolbutamide 250 mg, Dextromethorphan 30mg
Summary
Human safety studies will be carried out to test whether red clover botanical dietary supplements used by peri- and post-menopausal women are safe to use with Food and Drug Administration (FDA)-approved drugs. To test this, a red clover dietary supplement (previously tested in women at the University of Illinois at Chicago without any harmful effects) will be given with four selected FDA-approved drugs to determine if the Licorice supplement can increase or decrease how these medications are absorbed, metabolized and excreted by the human body. Preclinical studies predict that the licorice supplement might affect the metabolism or break down of these probe drugs.
Primary Outcome
- Area Under the Curve (AUC)