Melatonin Plus Aminoacids for Sarcopenic Elderly
Melatonin Plus Aminoacids for Sarcopenic Elderly
NCT ID: NCT03784495 Phase: NA Status: COMPLETED Enrollment: 159 Completion: 2015-06-01
Conditions
Sarcopenia
Interventions
Melatonin 1mg, Essential Aminoacids (eAA), Essential Aminoacids + melatonin, Placebo
Summary
To evaluate the effectiveness of melatonin and essential aminoacid supplementation on body composition, protein metabolism, strength and inflammation. The investigators performed a Randomized controlled parallel groups preliminary trial in 159 elderly sarcopenic people (42/117 men/women) assigned to 4 groups: isocaloric placebo (P, n=44), melatonin (M, 1 mg/daily, n=42,), essential aminoacids (eAA 4 g/daily, n=40) or eAA plus melatonin (eAAM, 4 g eAA and 1 mg melatonin/daily, n= 30). The period of intervention was 4 weeks. Data from body composition (DXA), strength (handgrip test) and biochemical parameters for the assessment of protein metabolism (albumin) and inflammation (PRC) were collected at baseline and after the 4-week intervention
Primary Outcome
Change in Total Fat Mass and Total Free Fat Mass (DXA)