The Effect of Probiotic Intake on Intestinal Permeability in Healthy Adults
The Effect of Probiotic Intake on Intestinal Permeability in Healthy Adults
NCT ID: NCT03611400 Phase: NA Status: COMPLETED Enrollment: 39 Completion: 2019-04-15
Conditions
Intestinal Barrier Function
Interventions
Probiotic, Placebo
Summary
In this double blind, crossover study participants will take a placebo for 3 weeks each. Gut permeability will be assessed weekly using food-grade sugar molecules. On the second week, participants will take aspirin, which will make their intestine permeable to the sugars. Participants will be asked to provide urine and stool samples to assess gut permeability and microbial communities. No change in permeability to the small sugar probes is anticipated with the probiotic.
Primary Outcome
Gastroduodenal Permeability