In Vitro And Ex Vivo Anti-Inflammatory Activities Of Salmon Polar Lipids
In Vitro And Ex Vivo Anti-Inflammatory Activities Of Salmon Polar Lipids
NCT ID: NCT03603769 Phase: NA Status: COMPLETED Enrollment: 6 Completion: 2019-01-31
Conditions
Cardiovascular Diseases
Interventions
Food supplement capsules containing Salmon-Polar Lipids, Placebo food supplement capsule
Summary
The aim of this project is to study the effects of a new-developed food-supplement that contains bioactive polar lipids derived from organic farmed Irish salmon for the beneficial promotion of cardiovascular health. The health claims that will be formulated for this nutraceutical are based on EFSA guidelines "The scientific requirements for health claims related to antioxidants, oxidative damage and cardiovascular health" and in particular paragraph 5.4, "Claims on reduced platelet aggregation" "Platelet hyperactivity and hypercoagulability states are more commonly observed in subjects with cardiovascular (CV) risk factors. Healthy subjects at very low risk of CV disease normally have non-activated circulating platelets. Decreasing platelet aggregation in subjects with platelet activation during sustained exposure to the food/constituent (e.g. four weeks) would be a beneficial physiological effect".
Within this study, the postprandial effects of this novel food supplement against platelet aggregation and inflammation are going to be exploited ex vivo in blood from human subjects as described in previously established procedures.
Primary Outcome
Postprandial effect of Supplement/placebo on human platelet aggregation induced by Platelet Activating Factor (PAF)