Effects of Riboflavin on Faecalibacterium Prausnitzii and the Gut Microbiota
Effects of Riboflavin on Faecalibacterium Prausnitzii and the Gut Microbiota
NCT ID: NCT02929459 Phase: PHASE2 Status: COMPLETED Enrollment: 105 Completion: 2019-12-01
Conditions
Gut Microbiota
Interventions
Riboflavin Dose 1, Riboflavin Dose 2, Placebo
Summary
The purpose of this trial is to investigate comprehensively the effect of riboflavin supplementation on the abundance of F. prausnitzii and on other members of the gut microbiota in faeces of healthy volunteers. Additionally it will be assessed whether riboflavin supplementation affects the abundance of potentially pathogenic bacteria such as adherent invasive E. coli (AIEC). Finally, the effect of riboflavin supplementation on the production of Short Chain Fatty Acids, the release of gut hormones and potential changes in glucose homeostasis and appetite perception will be assessed.
Primary Outcome
Number of F. prausnitzii per gram faeces