Effect of L-Arginine and Pycnogenol on Light to Moderate Hypertension and Endothelial Function
Effect of L-Arginine and Pycnogenol on Light to Moderate Hypertension and Endothelial Function
NCT ID: NCT02392767 Phase: NA Status: COMPLETED Enrollment: 25 Completion: 2015-08
Conditions
Endothelial Dysfunction, Hyperhomocysteinemia, Hypertension Grade I, Subgroup "Borderline" (WHO)
Interventions
Verum, Placebo
Summary
The effect of a combination product (Verum ) with L-arginine, Pycnogenol, vitamin K2, R-(+)-alpha-lipoic acid and vitamins B6, B12 and folic acid is investigated in a double blind placebo-controlled cross-over study. Volunteers with hypertension and hyperhomocysteinemia are randomly assigned to the dietary supplement or placebo.
Primary Outcome
Change in Endothelial Function Between the Visit at Start of Supplementation Phase and the Visit on the Final Day of the 4 Week Supplementation Phase (Delta "lnRHI")