Acetazolamide and Spironolactone to Increase Natriuresis in Congestive Heart Failure

NCT ID: NCT01973335 Phase: PHASE4 Status: COMPLETED Enrollment: 34 Completion: 2017-10

Conditions

Heart Failure

Interventions

Combination therapy with acetazolamide and low-dose loop diuretics, High-dose loop diuretics, Upfront therapy with oral spironolactone

Summary

This study has two primary objectives:

1. To compare combination therapy with acetazolamide and low-dose loop diuretics versus high-dose loop diuretics (standard of care) in patients with acute decompensated heart failure at high risk for diuretic resistance.
2. To demonstrate the safety and efficacy of upfront therapy with spironolactone in addition to loop diuretic therapy in patients with acute decompensated heart failure at high risk for diuretic resistance.

Primary Outcome

Acetazolamide Arm: Natriuresis 24 h

Source

ClinicalTrials.gov