Flavonoids, Blood Pressure and Blood Vessel Function
Flavonoids, Blood Pressure and Blood Vessel Function
NCT ID: NCT01530893 Phase: NA Status: COMPLETED Enrollment: 64 Completion: 2013-12
Conditions
Cardiovascular Disease Risk Reduction
Interventions
Flavanone - supplement, Flavanone - food, Flavanone - placebo, Isoflavone - supplement, Isoflavone - food, Isoflavone - placebo, Isoflavone - metabolite supplement, Flavan-3-ol - supplement, Flavan-3-ol - food, Flavan-3-ol - placebo
Summary
The primary aim of this placebo-controlled study is to determine whether flavonoids beneficially affect markers of cardiovascular disease risk in healthy subjects at elevated cardiovascular risk.
The underlying mechanisms of action of flavonoids will be assessed on blood biomarkers and we will assess the effects of the food matrix, and aspects of isoflavone metabolism.
Primary Outcome
Change from baseline in blood vessel control (pressure and endothelial function) at time points coinciding with postprandial [anticipated] peak plasma flavonoid concentration.