A Single Supplement of a Standardised Bilberry Extract Modifies Glycaemic Response
A Single Supplement of a Standardised Bilberry Extract Modifies Glycaemic Response
NCT ID: NCT01245270 Phase: NA Status: COMPLETED Enrollment: 8 Completion: 2013-08
Conditions
Type 2 Diabetes
Interventions
Bilberry capsule first, then control cap, Control capsule first then bilberry cap
Summary
Dietary strategies for alleviating health complications associated with type 2 diabetes (T2D) are being pursued as alternatives to pharmaceutical interventions. Berries such as bilberries that are rich in polyphenols may influence carbohydrate digestion and absorption and thus postprandial glycaemia. In addition berries have been reported to alter incretins as well as to have anti-oxidant and anti-inflammatory properties that may also affect postprandial glycaemia. This study investigated the acute affect of a standardised bilberry extract on glucose metabolism in T2D.
Eight male volunteers with T2D controlling their diabetes by diet and lifestyle alone were given a single oral capsule of either 0.47g standardized bilberry extract (36% (w/w) anthocyanins) which equates to ∼50 g of fresh bilberries or placebo followed by a polysaccharide drink (equivalent to 75 g glucose) in a double blinded cross over intervention with a two week washout period.
This study demonstrates that the ingestion of a concentrated bilberry extract reduces postprandial glycaemia and insulin in volunteers with T2D. The most likely mechanism for the lower glycaemic response involves reduced rates of carbohydrate digestion and/or absorption.
Primary Outcome
Plasma Glucose iAUC (Incremental Area Under the Curve; mM*Min)