Conjugated Linoleic Acid Supplementation Study
Conjugated Linoleic Acid Supplementation Study
NCT ID: NCT01234636 Phase: NA Status: COMPLETED Enrollment: 50 Completion: 2012-11
Conditions
Cardiovascular Disease
Interventions
Placebo oil
Summary
Cardiovascular disease is a major cause of mortality worldwide resulting in one out of three global deaths. One of the main characteristics of cardiovascular disease is impaired blood flow and increased formation of clots. Platelets are clot-forming cells responsible for prevention of bleeding. However, in disease state they may be overly activated and tend to stick to each other, promoting blood clots and blockage of vessels.
Conjugated linoleic acids (CLA) are unique fatty acids present in dairy food products and beef which would help to prevent platelets from clotting and thus help to prevent cardiovascular disease. However, the mechanisms by which those fatty acids affect platelet function are not yet fully understood. We designed a human intervention study assessing the mechanisms by which CLA beneficially affect platelet function and markers of haemostasis and inflammation in humans.
Primary Outcome
Change of expression of P-selectin and fibrinogen receptor activation on platelets by flow cytometry