Iron × Levodopa

Severity: MODERATE Evidence: probable

Mechanism

Iron forms complexes with levodopa, reducing its absorption.

Effect

Reduced levodopa efficacy; worsening Parkinson's symptoms

Management

Separate doses by at least 2 hours.

Source

Campbell NR, Hasinoff BB. Clin Pharmacol Ther 1991

⚠️ MODERATE INTERACTION: Monitor closely if this combination is used.

Disclaimer

This interaction record is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider before starting or stopping any supplement or medication.