Echinacea × Midazolam

Severity: MINOR Evidence: possible

Mechanism

Echinacea may inhibit intestinal CYP3A4 but induce hepatic CYP3A4, with net effect on midazolam being variable.

Effect

Variable effect on midazolam levels depending on route of administration

Management

Monitor for altered sedative effect. Minor clinical concern for most patients.

Source

Gurley BJ et al. Clin Pharmacol Ther 2004

Disclaimer

This interaction record is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider before starting or stopping any supplement or medication.