Collagen Matrix for Periodontal Plastic Surgery Procedures: A Meta-analysis Update

source extracted confidence: high 2026-04-09
#collagen #connective-tissue #gingiva #gingival-recession #humans

Collagen Matrix for Periodontal Plastic Surgery Procedures: A Meta-analysis Update

Xu et al., 2019 | Int J Periodontics Restorative Dent | Meta Analysis

Citation

Xu Chunmei, Wang QianTing, ... Zhao Lei. Collagen Matrix for Periodontal Plastic Surgery Procedures: A Meta-analysis Update. Int J Periodontics Restorative Dent. 2019;39(4):e129-e155. doi:10.11607/prd.3814

Abstract

This review aims to evaluate the effectiveness of a collagen matrix (CM) utilized in periodontal plastic surgeries around natural teeth and implants. This review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Review Manager 5.3 software was used for data analysis. Subgroup analyses were conducted by defect categories and follow-up periods. The GRADE system was applied to classify the quality of evidences. Out of 3,652 articles in the literature, 14 studies were included, totaling 1,260 defects in 565 participants. The meta-analysis showed that CM is superior to coronally advanced flaps (CAF) regarding gains in mean root coverage (MRC) and width of keratinized tissue (KTW). Insufficient evidence demonstrated that CM had higher complete root coverage (CRC). Connective tissue graft (CTG) presented better results in CRC, MRC, and KTW. Greater KTW was also found favoring CTG in implants. In subgroup analysis, moderate evidence showed that, compared to CTGs, CMs present similar results in CRC, MRC, and KTW when treating single gingival recessions. CTGs showed greater efficiency in KTW of multiple gingival recessions and long-term observations. CM presents suitable capabilities as an alternative to soft tissue graft, while CTG still shows better results in most clinical parameters.

Key Findings

CM presents suitable capabilities as an alternative to soft tissue graft, while CTG still shows better results in most clinical parameters.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 565
Age Range See abstract
Condition See abstract

MeSH Terms

  • Collagen
  • Connective Tissue
  • Gingiva
  • Gingival Recession
  • Humans
  • Surgery, Plastic
  • Tooth Root
  • Treatment Outcome

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Review
  • Vertical: collagen

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09