Melatonin influence in ovary transplantation: systematic review

source extracted confidence: high 2026-04-09
#animals #antioxidants #apoptosis #female #graft-survival

Melatonin influence in ovary transplantation: systematic review

Shiroma et al., 2016 | J Ovarian Res | Systematic Review

Citation

Shiroma M E, Botelho N M, ... Soares J M. Melatonin influence in ovary transplantation: systematic review. J Ovarian Res. 2016-Jun-10;9(1):33. doi:10.1186/s13048-016-0245-8

Abstract

Melatonin is an indolamine produced by the pineal gland and it can exert a potent antioxidant effect. Its free radical scavenger properties have been used to advantage in different organ transplants in animal experiments. Several concentrations and administration pathways have been tested and melatonin has shown encouraging beneficial results in many transplants of organs such as the liver, lungs, heart, pancreas, and kidneys. The objective of the present study was to review the scientific literature regarding the use of melatonin in ovary transplantation. A systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was carried out using the Cochrane and Pubmed databases and employing the terms 'melatonin' AND 'ovary' AND 'transplantation.' After analysis, 5 articles were extracted addressing melatonin use in ovary transplants and involving 503 animals. Melatonin enhanced various graft aspects like morphology, apoptosis, immunological reaction, revascularization, oxidative stress, and survival rate. Melatonin's antioxidative and antiapoptotic properties seemingly produce positive effects on ovarian graft activity. Despite the promising results, further studies in humans need to be conducted to consolidate its use, as ovary transplantation for fertility preservation is gradually being moved from the experimental stage to a clinical setting.

Key Findings

Despite the promising results, further studies in humans need to be conducted to consolidate its use, as ovary transplantation for fertility preservation is gradually being moved from the experimental stage to a clinical setting.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition stress

MeSH Terms

  • Animals
  • Antioxidants
  • Apoptosis
  • Female
  • Graft Survival
  • Humans
  • Melatonin
  • Neovascularization, Physiologic
  • Organ Transplantation
  • Ovary
  • Oxidative Stress

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: melatonin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09