Magnesium Glycinate

1 research sources Also known as: magnesium bisglycinate glycinate chelated magnesium
240 Products on Market
220.0 mg Median Dose
🟡 79/100 Market Safety Score
1 Research Sources
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Claims vs. Evidence

75% Evidence-Backed
25% Unsupported
88% Structure/Function
Claim Type% of ProductsEvidence RequiredStatus
All Other 100% Tier D (Unclassified) ✅ Supported
Structure/Function 88% Tier C (DSHEA Structure/Function (no pre-approval)) ⚠️ Unsupported
Nutrient 59% Tier D (Unknown) ✅ Supported
No Claim 0% Tier D (No claim on label) ✅ Supported

Research by Topic

Research Evidence (1)

Clinical Trial: 1
B Magnesium Bisglycinate Supplementation in Healthy Adults Reporting Poor Sleep: A Randomized, Placebo-Controlled Trial
Clinical Trial Nature and science of sleep 2025 n=155

PURPOSE: To assess the effects of magnesium bisglycinate supplementation on insomnia symptoms in healthy adults reporting poor sleep quality. PATIENTS AND METHODS: This randomized, double-blind, placebo-controlled trial enrolled 155 adults aged 18-65...

Details

Magnesium Glycinate

Overview

Magnesium glycinate (also called magnesium bisglycinate) is a chelated form of magnesium where magnesium is bound to two glycine molecules.

Properties

Property Value
Chemical Formula Mg(C₂H₄NO₂)₂
Bioavailability High
Elemental Mg Content ~14%
Absorption Good, minimal laxative effect

Advantages

  • High bioavailability: Chelated form enhances absorption
  • Gentle on GI: Minimal laxative effect compared to other forms
  • Glycine synergy: Glycine itself may support sleep and relaxation
  • Good tolerability: Well-tolerated at therapeutic doses

Evidence for Sleep

Clinical trials using magnesium glycinate/bisglycinate for sleep: - Schuster et al. 2025 (PMID: 40918053): 250mg elemental Mg, 4 weeks, improved ISI scores - Generally shows positive results in sleep-deficient populations

Comparison to Other Forms

Form Bioavailability GI Tolerance Best For
Glycinate High Excellent Sleep, anxiety, daily use
Citrate High Good Constipation, general supplementation
Oxide Low Fair Not recommended for CNS effects
Threonate High Good Cognitive effects

Related Entities

Safety Notes

  • Generally well-tolerated
  • Less likely to cause diarrhea than citrate or oxide forms
  • Standard dosing: 200-400mg elemental magnesium

Entity page for magnesium glycinate compound

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