⚠️ Mechanism
Turmeric is a moderate inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
📋 Effect
Increased plasma levels of methadone (opioids), potentially leading to toxicity or enhanced adverse effects.
💊 Management
Monitor for increased adverse effects of methadone. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
Taking turmeric with opioids can be risky because it may cause the medication to build up to higher levels in your body. This increase in medication levels can raise the risk of experiencing more severe side effects.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.