⚠️ Mechanism
Turmeric is a weak inhibitor of CYP1A2, which decreases metabolism of CYP1A2 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
📋 Effect
Increased plasma levels of melatonin (melatonin), potentially leading to toxicity or enhanced adverse effects.
💊 Management
Monitor for increased adverse effects of melatonin. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
This combination may be moderately risky because turmeric can slow down the way your body breaks down melatonin. This may cause higher levels of melatonin to build up in your system, which could increase the risk of side effects.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.