⚠️ Mechanism
Turmeric is a moderate inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
📋 Effect
Increased plasma levels of cyclosporine (immunosuppressants), potentially leading to toxicity or enhanced adverse effects.
💊 Management
Monitor for increased adverse effects of cyclosporine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
This combination is dangerous because turmeric can prevent your body from breaking down immunosuppressants like cyclosporine properly. This can cause the medication to build up to unsafe levels in your blood, increasing the risk of serious side effects.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)