⚠️ Mechanism
Turmeric is a weak inhibitor of CYP1A2, which decreases metabolism of CYP1A2 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
📋 Effect
Increased plasma levels of acetaminophen (analgesics), potentially leading to toxicity or enhanced adverse effects.
💊 Management
Monitor for increased adverse effects of acetaminophen. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
This combination carries a moderate risk and may not be safe for everyone. Turmeric can slow down how your body processes certain pain relievers, which may cause the medication to build up to unsafe levels in your bloodstream.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.