⚠️ Mechanism
Saw Palmetto is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
📋 Effect
Increased plasma levels of sildenafil (pde5-inhibitors), potentially leading to toxicity or enhanced adverse effects.
💊 Management
Monitor for increased adverse effects of sildenafil. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
This combination may increase the risk of side effects. Saw Palmetto can slow down how your body breaks down PDE5 inhibitors, which may cause higher levels of the medication to build up in your bloodstream.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)
Supporting Research
Serenoa repens for benign prostatic hyperplasia
Serenoa repens for benign prostatic hyperplasia
Non-hormonal treatment for male infertility: the potential role of Serenoa repens, selenium and lycopene
Comparison of Serenoa repens With Tamsulosin in the Treatment of Benign Prostatic Hyperplasia: A Systematic Review and Meta-Analysis
Effects of dietary supplements on androgenetic alopecia: a systematic review and network meta-analysis
Benign prostate hyperplasia and nutrition
American palm ethnomedicine: a meta-analysis
Benign prostatic hyperplasia and male lower urinary tract symptoms (LUTS)
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.