⚠️ Mechanism
L-tryptophan is a serotonin precursor. SSRIs block serotonin reuptake. Combined use dramatically increases synaptic serotonin.
📋 Effect
Serotonin syndrome (potentially fatal)
💊 Management
Avoid combination. Serotonin syndrome is a medical emergency.
Plain Language Summary
This combination is dangerous and can be life-threatening. Taking these together can cause an excessive buildup of serotonin in your body, which may lead to a serious condition called serotonin syndrome.
Source
FDA MedWatch; Sternbach H. Am J Psychiatry 1991
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.