⚠️ Mechanism
MAOIs prevent serotonin breakdown. L-tryptophan increases serotonin production. Combined use causes massive serotonin accumulation.
📋 Effect
Serotonin syndrome (potentially fatal)
💊 Management
Absolutely avoid combination.
Plain Language Summary
This combination is dangerous. L-tryptophan increases serotonin production, and because MAOIs prevent the body from breaking serotonin down, using them together can cause a life-threatening buildup of serotonin.
Source
FDA MAOI labeling; Sternbach H. Am J Psychiatry 1991
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.