⚠️ Mechanism
Grapefruit is a moderate inhibitor of P-gp, which decreases metabolism of P-gp substrates, potentially increasing their plasma concentrations and risk of adverse effects.
📋 Effect
Increased plasma levels of digoxin (digoxin), potentially leading to toxicity or enhanced adverse effects.
💊 Management
Monitor for increased adverse effects of digoxin. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
This combination is dangerous. Grapefruit can cause the level of digoxin in your blood to rise to unsafe levels, which increases your risk of experiencing toxic side effects.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.