⚠️ Mechanism
Grapefruit is a strong inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
📋 Effect
Increased plasma levels of doxorubicin (chemotherapy), potentially leading to toxicity or enhanced adverse effects.
💊 Management
Monitor for increased adverse effects of doxorubicin. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
This is a dangerous combination. Grapefruit can prevent your body from breaking down chemotherapy properly, which may cause the drug to build up to unsafe levels in your bloodstream. This increase in medication levels can lead to more severe side effects.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)