⚠️ Mechanism
Grapefruit is a moderate inhibitor of P-gp, which decreases metabolism of P-gp substrates, potentially increasing their plasma concentrations and risk of adverse effects.
📋 Effect
Increased plasma levels of fexofenadine (antihistamines), potentially leading to toxicity or enhanced adverse effects.
💊 Management
Monitor for increased adverse effects of fexofenadine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
This combination carries a moderate risk. Grapefruit can prevent your body from breaking down certain antihistamines properly, which may lead to higher levels of the medication in your system and an increased chance of side effects.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.