⚠️ Mechanism
Dong Quai is a weak inhibitor of CYP2D6, which decreases metabolism of CYP2D6 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
📋 Effect
Increased plasma levels of dextromethorphan (antitussives), potentially leading to toxicity or enhanced adverse effects.
💊 Management
Monitor for increased adverse effects of dextromethorphan. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
This combination may be risky because Dong Quai can slow down how your body breaks down certain cough medicines. This can cause the medicine to build up in your system, which may increase your risk of experiencing side effects.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.