Dong Quai × Antiemetics Interaction — Severity, Mechanism & Management

⚠️ Mechanism

Dong Quai is a weak inhibitor of CYP2D6, which decreases metabolism of CYP2D6 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

📋 Effect

Increased plasma levels of ondansetron (antiemetics), potentially leading to toxicity or enhanced adverse effects.

💊 Management

Monitor for increased adverse effects of ondansetron. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Plain Language Summary

This combination may cause concern because Dong Quai can prevent your body from breaking down certain antiemetic drugs, like ondansetron, at a normal rate. This can lead to higher levels of the medication in your system, which may increase the risk of side effects.

Source

Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)

Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.