⚠️ Mechanism
Cranberry may inhibit CYP2C9, reducing warfarin metabolism. Evidence is conflicting but cases of increased INR exist.
📋 Effect
Possible increased INR and bleeding risk
💊 Management
Monitor INR with cranberry products. Moderate intake is usually safe.
Plain Language Summary
This combination carries a moderate risk because cranberry may slow down how your body processes warfarin. This can cause the medication to build up in your system, which may increase your risk of bleeding.
Source
Greenblatt DJ, von Moltke LL. J Clin Pharmacol 2005; Iseme BA et al. Clin Pharmacol Ther 2007
Supporting Research
Study of Oral Anthocyanins on Insulin Resistance
The Effect of Cranberry Extract Supplementation on Cardiovascular Risk Factors in Obese, Insulin Resistant Humans
Adverse Event Profile: Cranberry
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.