⚠️ Mechanism
Cranberry is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
📋 Effect
Increased plasma levels of salmeterol (beta2-agonists), potentially leading to toxicity or enhanced adverse effects.
💊 Management
Monitor for increased adverse effects of salmeterol. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
This combination carries a moderate risk because cranberry can slow down how your body breaks down certain beta-2 agonist medications. This may cause higher levels of the medicine to build up in your system, which could increase the risk of side effects.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)
Supporting Research
Study of Oral Anthocyanins on Insulin Resistance
The Effect of Cranberry Extract Supplementation on Cardiovascular Risk Factors in Obese, Insulin Resistant Humans
Adverse Event Profile: Cranberry
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.