Effect of garlic on total serum cholesterol. A meta-analysis

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#administration-oral #cholesterol #dosage-forms #female #garlic

Effect of garlic on total serum cholesterol. A meta-analysis

Warshafsky et al., 1993 | Ann Intern Med | Meta Analysis

Citation

Warshafsky S, Kamer R S, Sivak S L. Effect of garlic on total serum cholesterol. A meta-analysis. Ann Intern Med. 1993-Oct-01;119(7 Pt 1):599-605

Abstract

OBJECTIVE: To assess the size and consistency of garlic's effect on total serum cholesterol in persons with cholesterol levels greater than 5.17 mmol/L (200 mg/dL). DATA SOURCES: Clinical trials were identified by a computerized literature search of MEDLINE and by an assessment of the bibliographies of published studies and reviews. STUDY SELECTION: Trials were selected if they were randomized and placebo-controlled and if at least 75% of their patients had cholesterol levels greater than 5.17 mmol/L (200 mg/dL). Studies were excluded if they did not provide enough data to compute effect size. Five of 28 studies were selected for review. DATA EXTRACTION: Details of study design, patient characteristics, interventions, duration of therapy, and cholesterol measurements were extracted by one author and were verified by another. DATA SYNTHESIS: Study quality was evaluated by multiple reviewers using a closed-ended questionnaire. Patients treated with garlic consistently showed a greater decrease in total cholesterol levels compared with those receiving placebo. Meta-analysis of homogeneous trials estimated a net cholesterol decrease attributable to garlic of 0.59 mmol/L (95% CI, 0.44 to 0.74) (23 mg/dL [CI, 17 to 29]) (P < 0.001). CONCLUSIONS: Meta-analysis of the controlled trials of garlic to reduce hypercholesterolemia showed a significant reduction in total cholesterol levels. The best available evidence suggests that garlic, in an amount approximating one half to one clove per day, decreased total serum cholesterol levels by about 9% in the groups of patients studied.

Key Findings

Meta-analysis of the controlled trials of garlic to reduce hypercholesterolemia showed a significant reduction in total cholesterol levels. The best available evidence suggests that garlic, in an amount approximating one half to one clove per day, decreased total serum cholesterol levels by about 9% in the groups of patients studied.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 28
Age Range See abstract
Condition See abstract

MeSH Terms

  • Administration, Oral
  • Cholesterol
  • Dosage Forms
  • Female
  • Garlic
  • Humans
  • Hypercholesterolemia
  • Male
  • Middle Aged
  • Plants, Medicinal
  • Research Design
  • Sensitivity and Specificity

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis
  • Vertical: garlic

Provenance

  • PMID: 8363171
  • DOI: (not available)
  • PMCID: Not in PMC
  • Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09