Clinical investigation of the antidepressant effectiveness of hypericum

Harrer et al., 1994 | J Geriatr Psychiatry Neurol | Meta Analysis

Citation

Harrer G, Schulz V. Clinical investigation of the antidepressant effectiveness of hypericum. J Geriatr Psychiatry Neurol. 1994-Oct;7 Suppl 1:S6-8

Abstract

To date, 25 controlled therapy studies have investigated the antidepressive effectiveness of hypericum extracts. A total of 1592 treatment cases have been included. The dosage was typically 300 to 900 mg total extract daily; the therapy duration was 2 to 6 weeks. Fifteen studies were performed comparing hypericum extracts with placebo, 10 studies as comparative studies. This paper presents an overview of their results.

Key Findings

This paper presents an overview of their results.

Outcomes Measured

Requires manual extraction

Population

Field	Value
Population	See abstract
Sample Size	10
Age Range	See abstract
Condition	See abstract

MeSH Terms

Antidepressive Agents
Humans
Hypericum
Perylene
Plant Extracts
Plants, Medicinal
Quercetin
Xanthenes

Evidence Classification

Level: Meta Analysis
Publication Types: Journal Article, Meta-Analysis
Vertical: st.-john's-wort

Provenance

PMID: 7857512
DOI: (not available)
PMCID: Not in PMC
Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09