THE USE OF HERBAL MEDICINES IN PREVENTING CANCER MUTATIONS IN ANIMAL MODELS EXPOSED TO TOXICANTS: A SYSTEMATIC REVIEW

source extracted confidence: high 2026-04-09
#animals #disease-models-animal #mutation #neoplasms #humans

THE USE OF HERBAL MEDICINES IN PREVENTING CANCER MUTATIONS IN ANIMAL MODELS EXPOSED TO TOXICANTS: A SYSTEMATIC REVIEW

Iztleuov et al., 2025 | Georgian Med News | Systematic Review

Citation

Iztleuov Y, Iztleuov M, ... Kydyrbayeva E. THE USE OF HERBAL MEDICINES IN PREVENTING CANCER MUTATIONS IN ANIMAL MODELS EXPOSED TO TOXICANTS: A SYSTEMATIC REVIEW. Georgian Med News. 2025-Sep(366):84-92

Abstract

AIM OF THE STUDY: To systematically evaluate preclinical evidence on the protective effects of herbal interventions against toxicant-induced genetic and epigenetic alterations in animal models. MATERIALS AND METHODS: A systematic review (2015-2025) across PubMed, Scopus, Web of Science, Cochrane, and Google Scholar identified six animal studies on herbal protection against toxicant-induced mutations. SYRCLE's tool showed generally robust designs. RESULTS AND DISCUSSION: Six rodent studies investigated exposures such as BPA, busulfan, testosterone propionate, OVA, and prenatal stress. Herbal treatments (carob, ginger, ASHMI, BSTJF, Cuscuta flavonoids) were administered via diverse routes and durations. All studies reported significant improvements (P < 0.05 to P < 0.001) in genetic and epigenetic outcomes, including enhanced sperm DNA integrity, reduced inflammation, improved neurobehavior, hormonal regulation, and restored DNA methylation patterns. Transgenerational assessments consistently supported the potential of herbal therapies to mitigate inheritable mutation risks. Herbal medicines show protective effects against toxicant-induced genetic and epigenetic changes in animal models, suggesting potential preventive strategies, while long-term and mechanistic studies are needed to confirm human applicability.

Key Findings

Herbal medicines show protective effects against toxicant-induced genetic and epigenetic changes in animal models, suggesting potential preventive strategies, while long-term and mechanistic studies are needed to confirm human applicability.

Outcomes Measured

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Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition stress

MeSH Terms

  • Animals
  • Disease Models, Animal
  • Mutation
  • Neoplasms
  • Humans
  • Epigenesis, Genetic
  • Herbal Medicine
  • Male
  • Female

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: ginger

Provenance

  • PMID: 41314190
  • DOI: (not available)
  • PMCID: Not in PMC
  • Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09