Efficacy and safety of injectable sodium hyaluronate with vitamin C, tranexamic acid, and glutathione for pigmented dark circles.

Abstract

BACKGROUND: Periorbital hyperpigmentation (POH) is a common benign condition affecting facial esthetics. This study evaluated the efficacy and safety of an injectable sodium hyaluronate complex solution combined with vitamin C, tranexamic acid, and glutathione for POH treatment. METHOD: 120 POH patients were randomly divided into two groups. All participants received two treatment injections at two-week intervals. Evaluations were conducted at 4 and 12 weeks posttreatment, assessing periorbital grayscale values, clinical grading changes, Global Esthetic Improvement Score, Dermatologic Quality of Life Index (DLQI), and patient satisfaction. RESULT: The treatment group demonstrated significant improvements in grayscale values (162.10 ± 14.22 to 169.66 ± 13.43) and reduced pigmentation differences from normal skin (23.01 ± 12.73 to 14.44 ± 14.79). The control group showed no significant changes. Treatment group patients exhibited significantly better grayscale values (p < .05), improved DLQI scores, and reduced dark circle severity (p < .05). 96.7% of treated patients reported satisfaction with visible esthetic improvements. CONCLUSION: The hyaluronate-based combination therapy effectively improved POH, demonstrating significant esthetic enhancement and quality of life improvement. This minimally invasive approach proved safe, effective, and highly satisfactory, presenting a promising treatment option for periorbital hyperpigmentation. EVIDENCE LEVEL: Level II.