A systematic review and meta-analysis to investigate the effectiveness of exosome for diabetic wounds

source extracted confidence: high 2026-04-09
#wound-healing #exosomes #humans #animals

A systematic review and meta-analysis to investigate the effectiveness of exosome for diabetic wounds

Chen et al., 2025 | J Tissue Viability | Meta Analysis

Citation

Chen Lan, Liu Jia, ... Luo Chaoxi. A systematic review and meta-analysis to investigate the effectiveness of exosome for diabetic wounds. J Tissue Viability. 2025-Aug;34(3):100917. doi:10.1016/j.jtv.2025.100917

Abstract

AIM: Exosomes, small endosome-derived membrane vesicles, have shown significant potential as wound healing therapies. However, translating experimental research into commercially available treatments remains a challenge. OBJECTIVES: This systematic review and meta-analysis provide a comprehensive evaluation of the current research on exosome-based wound healing therapies. MATERIALS AND METHODS: A systematic search of PubMed and Google Scholar was conducted to identify full-text articles published between 2010 and February 2024 on mammalian-derived exosomes in wound healing. Of 138 identified studies, 19 met the inclusion criteria for meta-analysis. RESULTS: Exosome-based therapies were found to enhance wound healing by promoting angiogenesis, re-epithelialization, and collagen deposition while reducing scar formation. However, research in this area is highly variable, with differences in cell sources, biomaterials, and delivery methods. CONCLUSIONS: Further comparative studies are needed to optimize cellular sources, delivery systems, and biomaterials. The reliance on rodent models remains a limitation, as progress toward large-scale testing and more advanced in vivo models has been slow. Addressing these challenges is crucial for the clinical translation of exosome-based therapies into scalable, commercially viable wound healing treatments.

Key Findings

Exosome-based therapies were found to enhance wound healing by promoting angiogenesis, re-epithelialization, and collagen deposition while reducing scar formation. However, research in this area is highly variable, with differences in cell sources, biomaterials, and delivery methods.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Wound Healing
  • Exosomes
  • Humans
  • Animals

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Systematic Review, Meta-Analysis
  • Vertical: collagen

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09