A comprehensive examination and analysis of the effectiveness and safety of finerenone for the treatment of diabetic kidney disease: a systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#humans #diabetic-nephropathies #naphthyridines #mineralocorticoid-receptor-antagonists #covid-19

A comprehensive examination and analysis of the effectiveness and safety of finerenone for the treatment of diabetic kidney disease: a systematic review and meta-analysis

Chen et al., 2024 | Front Endocrinol (Lausanne) | Meta Analysis

Citation

Chen Jianyu, Xue Jisu, ... Chen Jihong. A comprehensive examination and analysis of the effectiveness and safety of finerenone for the treatment of diabetic kidney disease: a systematic review and meta-analysis. Front Endocrinol (Lausanne). 2024;15:1461754. doi:10.3389/fendo.2024.1461754

Abstract

OBJECTIVES: The study will evaluate the effectiveness and safety of finerenone in patients diagnosed with diabetic kidney disease (DKD). METHODS: Various databases including PubMed, Sinomed, Web of Science, Embase, Clinical Trials, and Cochrane Library were systematically reviewed for pertinent studies published from the beginning to February 2024.This meta-analysis utilized RevMan 5.3 and Stata 15.1. RESULTS: The analysis of 4 randomized controlled trials involving 13,943 participants found that finerenone treatment significantly decreased the urine albumin-to-creatinine ratio compared to placebo. Additionally, the risk of COVID-19, cardiovascular events, and estimated glomerular filtration rate(eGFR) reduction of at least 40% were all significantly lower in the finerenone treatment group. However, the finerenone group did experience higher baseline increases in serum potassium levels. The meta-analysis revealed that there was no variation in the likelihood of general negative outcomes (RR 1.00, 95% CI 0.98, 1.01, I2 = 0%) and the occurrence of cancers (RR 0.99, 95% CI 0.83, 1.18,I2 = 0%) among the two categories. CONCLUSION: Our study demonstrates that finerenone has the potential to lower the chances of end-stage kidney disease, renal failure and cardiovascular mortality in individuals with diabetic kidney disease. It is important to monitor for hyperkalemia risk. The administration of finelidone among individuals with diabetic kidney disease may potentially mitigate the susceptibility to contracting COVID-19. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/, identifier CRD42024536612.

Key Findings

The analysis of 4 randomized controlled trials involving 13,943 participants found that finerenone treatment significantly decreased the urine albumin-to-creatinine ratio compared to placebo. Additionally, the risk of COVID-19, cardiovascular events, and estimated glomerular filtration rate(eGFR) reduction of at least 40% were all significantly lower in the finerenone treatment group. However, the finerenone group did experience higher baseline increases in serum potassium levels. The meta-analy

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population diabetic kidney disease
Sample Size 13943
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Diabetic Nephropathies
  • Naphthyridines
  • Mineralocorticoid Receptor Antagonists
  • COVID-19
  • Treatment Outcome
  • Randomized Controlled Trials as Topic
  • Glomerular Filtration Rate

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Systematic Review, Meta-Analysis, Journal Article
  • Vertical: potassium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09