Folate intake and the risk of endometrial cancer: A dose-response meta-analysis

source extracted confidence: high 2026-04-09
#humans #female #endometrial-neoplasms #folic-acid #dose-response-relationship-drug

Folate intake and the risk of endometrial cancer: A dose-response meta-analysis

Long et al., 2024 | Medicine (Baltimore) | Meta Analysis

Citation

Long Jiaye, Wang Du, ... Cui Kai. Folate intake and the risk of endometrial cancer: A dose-response meta-analysis. Medicine (Baltimore). 2024-Sep-20;103(38):e39775. doi:10.1097/MD.0000000000039775

Abstract

BACKGROUND: The relationship between folate intake and risk of endometrial cancer (EC) is debatable. The goal of this study was to examine the relationship between folate consumption and EC and then conduct a dose-response analysis in accordance with this. METHODS: Up until February 1, 2024, we conducted a thorough search using PubMed, EMBASE, the Cochrane Library, and Web of Science. Stata 14 software was used to analyze the findings of the article. The study protocol was registered in PROSPERO (CRD42024505943), and the meta-analysis was conducted in accordance with PRISMA guidelines. RESULTS: Nine case-control studies and 6 cohort studies were included, comprising 379,570 participants and 8660 EC cases. The highest level of folate consumption was associated with a 10% reduction in the occurrence of EC (relative risk [RR] = 0.90, 95% confidence intervals [CIs]: 0.78-1.05, I2 = 63.2%) compared to the lowest level of intake. The association exhibited a statistically significant linear trend (P = .231), with a combined RR of 0.974 (95% CI: 0.968-0.981) for each daily intake of 50 µg folate. CONCLUSION: Folate intake may reduce the risk of EC.

Key Findings

Nine case-control studies and 6 cohort studies were included, comprising 379,570 participants and 8660 EC cases. The highest level of folate consumption was associated with a 10% reduction in the occurrence of EC (relative risk [RR] = 0.90, 95% confidence intervals [CIs]: 0.78-1.05, I2 = 63.2%) compared to the lowest level of intake. The association exhibited a statistically significant linear trend (P = .231), with a combined RR of 0.974 (95% CI: 0.968-0.981) for each daily intake of 50 µg fola

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 379570
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Female
  • Endometrial Neoplasms
  • Folic Acid
  • Dose-Response Relationship, Drug
  • Risk Factors
  • Case-Control Studies

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: folate

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09