Elevated Vitamin B12, Risk of Cancer, and Mortality: A Systematic Review

Amado-Garzon et al., 2024 | Cancer Invest | Systematic Review

Citation

Amado-Garzon Sandra B, Molina-Pimienta Luisana, ... Buitrago-Lopez Adriana. Elevated Vitamin B12, Risk of Cancer, and Mortality: A Systematic Review. Cancer Invest. 2024-Jul;42(6):515-526. doi:10.1080/07357907.2024.2366907

Abstract

Vitamin B12 (B12) is a molecule involved in several biological. Abnormally high levels are frequently found, but their causes can be multiple, and consequences have not been clearly elucidated. The objective of this review was to summarize the current evidence on the associations of elevated B12 and the development of cancer, and all-cause mortality in adults. Six references looking at mortality and seven looking at cancer risk were included. The evidence suggests an association between elevated B12 with a higher risk of cancer, with risk ratios ranging 1,88 to 5,9. There was less consistent evidence linking vitamin B12 and mortality.

Key Findings

There was less consistent evidence linking vitamin B12 and mortality.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Vitamin B 12
  • Neoplasms
  • Risk Factors

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Systematic Review, Journal Article
  • Vertical: vitamin-b12

Provenance


Source extracted via PubMed E-utilities API on 2026-04-09