Vitamin D Levels in Patients with Noninfectious Uveitis: A Systematic Review and Meta-Analysis

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#humans #uveitis #vitamin-d #vitamin-d-deficiency #dietary-supplements

Vitamin D Levels in Patients with Noninfectious Uveitis: A Systematic Review and Meta-Analysis

Cunha et al., 2024 | Ocul Immunol Inflamm | Meta Analysis

Citation

Cunha Amaral Dillan, Takahashi Rafael, ... Noguera Louzada Ricardo. Vitamin D Levels in Patients with Noninfectious Uveitis: A Systematic Review and Meta-Analysis. Ocul Immunol Inflamm. 2024-Dec;32(10):2354-2362. doi:10.1080/09273948.2024.2367676

Abstract

PURPOSE: Vitamin D deficiency has been associated with higher rates of autoimmune disease, including noninfectious uveitis. This PRISMA-compliant review and meta-analysis aimed to analyze the correlation between noninfectious uveitis and vitamin D levels. METHODS: We searched PubMed, Embase, Cochrane, and Web of Science databases for studies, published in English, assessing vitamin D levels in patients diagnosed with noninfectious uveitis. The outcomes of interest were vitamin D deficiency, vitamin D mean level, vitamin D supplementation, and smoking rates. A subgroup analysis of inactive uveitis and active uveitis was performed. The heterogeneity was assessed with Cochrane Q-test and I2 statistics; p > 0.10 and I2 > 50% were considered significant for heterogeneity. Statistical analysis was conducted using Review Manager 5.3. RESULTS: 9 studies were included in the meta-analysis comprising a total of 10 711 patients, of whom 1,368 were diagnosed with noninfectious uveitis. Patients with noninfectious uveitis had worse results regarding vitamin D deficiency when compared with the control group (OR 0.58; CI 95% 0.44 to 0.77; p = 0.0002; I2 = 61%). Patients with inactive uveitis had better results towards vitamin D deficiency when compared with active uveitis (OR 5.00; CI 95% 2.84 to 8.81; p < 0.001; I2 = 0%). CONCLUSION: Our research supports the increasing evidence that associates vitamin D deficiency with noninfectious uveitis and its activity. Further investigation into the efficacy of vitamin D screening and supplementation in reducing the recurrence of uveitis is necessary.

Key Findings

9 studies were included in the meta-analysis comprising a total of 10 711 patients, of whom 1,368 were diagnosed with noninfectious uveitis. Patients with noninfectious uveitis had worse results regarding vitamin D deficiency when compared with the control group (OR 0.58; CI 95% 0.44 to 0.77; p = 0.0002; I2 = 61%). Patients with inactive uveitis had better results towards vitamin D deficiency when compared with active uveitis (OR 5.00; CI 95% 2.84 to 8.81; p < 0.001; I2 = 0%).

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population noninfectious uveitis had worse
Sample Size 711
Age Range See abstract
Condition deficiency

MeSH Terms

  • Humans
  • Uveitis
  • Vitamin D
  • Vitamin D Deficiency
  • Dietary Supplements

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Systematic Review, Journal Article, Meta-Analysis
  • Vertical: vitamin-d

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09