Effects of quercetin in preclinical models of Parkinson's disease: A systematic review

source extracted confidence: high 2026-04-09
#animals #humans #mice #rats #antioxidants

Effects of quercetin in preclinical models of Parkinson's disease: A systematic review

de et al., 2024 | Basic Clin Pharmacol Toxicol | Systematic Review

Citation

de Oliveira Vian Camila, Marinho Marcelo Augusto Germani, ... Horn Ana Paula. Effects of quercetin in preclinical models of Parkinson's disease: A systematic review. Basic Clin Pharmacol Toxicol. 2024-Jul;135(1):3-22. doi:10.1111/bcpt.14011

Abstract

Parkinson's disease (PD) is a neurodegenerative disease that affects dopaminergic neurons, thus impairing dopaminergic signalling. Quercetin (QUE) has antioxidant and neuroprotective properties that are promising for the treatment of PD. This systematic review aimed to investigate the therapeutic effects of QUE against PD in preclinical models. The systematic search was performed in PubMed, Scopus and Web of Science. At the final screening stage, 26 articles were selected according to pre-established criteria. Selected studies used different methods for PD induction, as well as animal models. Most studies used rats (73.08%) and mice (23.08%), with 6-OHDA as the main strategy for PD induction (38.6%), followed by rotenone (30.8%). QUE was tested immersed in oil, nanosystems or in free formulations, in varied routes of administration and doses, ranging from 10 to 400 mg/kg and from 5 to 200 mg/kg in oral and intraperitoneal administrations, respectively. Overall, evidence from published data suggests a potential use of QUE as a treatment for PD, mainly through the inhibition of oxidative stress, neuroinflammatory response and apoptotic pathways.

Key Findings

Overall, evidence from published data suggests a potential use of QUE as a treatment for PD, mainly through the inhibition of oxidative stress, neuroinflammatory response and apoptotic pathways.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition stress

MeSH Terms

  • Animals
  • Humans
  • Mice
  • Rats
  • Antioxidants
  • Apoptosis
  • Disease Models, Animal
  • Neuroprotective Agents
  • Oxidative Stress
  • Oxidopamine
  • Parkinson Disease
  • Parkinsonian Disorders
  • Quercetin
  • Rotenone

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: quercetin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09